Wahab Riaz is in as Umar Gul is out because of a knee injury.
Pakistan’s captain believes that batting second would help the team chase target.
This is the sixth ODI series between the two teams and Pakistan have never defeated the Proteas in a bilateral one-day series.
South Africa squad
AB de Villiers, KJ Abbott, HM Amla, F Behardien, F du Plessis, CA Ingram, RK Kleinveldt, R McLaren, DA Miller, M Morkel, RJ Peterson, AM Phangiso, GC Smith, DW Steyn, LL Tsotsobe
Misbah-ul-Haq, Abdur Rehman, Asad Shafiq, Imran Farhat, Junaid Khan, Kamran Akmal, Mohammad Hafeez, Mohammad Irfan, Nasir Jamshed, Saeed Ajmal, Shahid Afridi, Shoaib Malik, Umar Akmal, Umar Gul, Wahab Riaz, Younis Khan