Earlier Green shirts were all out at 338 in their first innings.
Saeed dismissed all five for just 41 including Protease skipper Graeme Smith, Hashim Amla and Jacques Kallis.
Saeed started his spell after 11 overs and Smith was his first victim. Within next two overs Saeed had Alviro Petersen, caught at short leg by Azhar Ali.
After tea break Petersen was followed by Amla, another victim of Saeed’s swing. Kallis and Faf du Plessis fall prey to his magic swing by the end of the day while AB de Villiers and Dean Elgar managed to survive.