Roque, 23, underwent surgery to remove a tumour in his pelvis last year, ESPN Soccernet reported.
A statement on Betis’ official website read: “The Real Betis player Miquel Roque Farrero, Miki Roque, had died today at the Instituto Dexeus de Barcelona hospital at the age of 23.
“Miki Roque had been battling pelvic cancer since March 2011, a struggle that he fought with fortitude and determination. Real Betis send their deepest condolences to the Roque family.’’
A Liverpool statement read: “Liverpool Football Club was today saddened to hear news that former player Miki Roque has lost his battle with cancer aged 23. Everyone at Liverpool Football Club would like to send their thoughts to Miki’s family at this sad time.’’