According to reports, three people were gunned down in Khuda Ki Basti area of the metropolis. Police said armed men shot dead three men managed to escape.
The bodies were shifted to a hospital for medico-legal formalities. A man was also shot dead in Kharadar by unknown armed men.
Police said a body was also found in Landhi Town area of Karachi.
Earlier on Thursday, at least nine people, including an Rangers inspector were killed in different parts of the city.