The country is now looking forward for international aid to sort out the causes of the fatal disease.
The disease starts with a rash on the hands and feet, and doctors said it can lead to liver problems and multiple organ failure.
Vietnam’s government conducted medical tests to find out the disease’s cause but to no avail.
The government said it will ask the World Health Organization (WHO) and the US Centre for Disease Control and Prevention to join its investigation.
The illness was first reported between April and December 2011 and then subsided, but broke out again last month.
Health workers say it responds well to early intervention but is difficult to treat once established.
Frightened residents of Reu village have laid branches across the path to the houses of infected people to try to isolate the outbreak.
“We have to block the entrances here to stop patients from getting out and spreading the disease,” one resident told Vietnamese TV.